PROJECT SUMMARY

Hydrogel dressings are an advanced and effective solution for treating severe, acute, and chronic wounds. Unlike traditional dressings, hydrogels do not adhere to the wound surface, reducing pain and discomfort during removal. Their ability to absorb exudate and maintain a moist environment supports faster and more efficient healing.

 

In this project, we develop biomimetic hydrogel dressings enriched with natural therapeutic agents, such as standardized Aloe vera extract, recognized for its wound-healing and anti-inflammatory properties. The hydrogels are based on natural polymers, including gelatin and dextran, which are biocompatible and safe for biological tissues. These materials are designed to provide controlled elasticity and a high capacity for exudate absorption.

A major innovation of the project is the one-step fabrication process using electron-beam irradiation. This technique enables both the cross-linking of the polymer network and the final sterilization of the dressing in a single technological stage. The resulting hydrogels support cell viability and promote the controlled release of active compounds, enhancing healing efficiency and improving patient comfort.

Specific Objectives of the HYDRO-THERA Project

• O1. Formulation of a biomimetic hydrogel containing standardized Aloe Vera extract, crosslinked and sterilized through accelerated electron-beam irradiation.
• O2. Investigation of the physicochemical stability and structural and morphological characterization of the biomimetic hydrogel.
• O3. Evaluation of the in vitro biological performance of the biomimetic hydrogel and determination of the therapeutic agent’s release profiles.
• O4. Demonstration of the hydrogel’s efficacy in cutaneous wound healing through in vitro biocompatibility studies.